Many people are skeptical of whether aging can be slowed or reversed. However, with recent advances in aging biology, scientists have discovered which factors can make us age faster or slower at the cellular level. Namely, with the recent renaissance in aging biology, researchers have identified the hallmarks of aging — biological drivers of aging that can be targeted with drugs or nutraceuticals to delay the aging process.
Researchers are rigorously testing which longevity technologies are most effective, and they are finding that combining them can generate synergy. It’s like a symphony: Each instrument on its own sounds nice, but together, they create something far greater. This synergy likely occurs because different longevity technologies target different hallmarks of aging. With synergy in mind, the scientists at Sergon have employed their world-renowned expertise to create Restorin.
In contrast to most other nutraceuticals, Restorin contains complementary technologies that elicit a synergistic effect by targeting multiple hallmarks of aging with patents sourced from leading institutions like Harvard University, Mayo Clinic, and Scripps Research. Moreover, the precursor to Restorin, Seragon’s SRN-901, has made headlines by showing that administering it to middle-aged mice increases their remaining lifespan by one-third, one of the greatest extensions of lifespan achieved.
Longevity Tech
Some longevity compounds have gotten a bad rap due to their unnecessary hype. A good example of this is the anti-diabetes drug metformin. While metformin may prolong the lifespan of type 2 diabetes patients, it does not appear to do the same for healthy individuals. Moreover, metformin has not been shown to prolong the lifespan of rodents, which is the gold standard for determining whether a compound is effective at promoting longevity. As metformin was once a promising longevity compound, other compounds have since accumulated more positive results and validity.
Some of these compounds work by inhibiting a protein complex called mTOR, which, when overactivated, speeds up aging. The hope is that suppressing mTOR could turn back the biological clock, at least at the cellular level. One way suppressing mTOR may turn back the clock is by activating autophagy, the process our cells use to recycle damaged cellular components. For example, the autophagy of mitochondria (mitophagy) helps clear out damaged mitochondria, improving mitochondrial health.
Here is where the synergy of Restorin’s components comes into play, as there is substantial overlap between the hallmarks of aging, which includes the dysregulation of mTOR, impairments in autophagy, and defective mitochondria. Restorin’s longevity technologies can target each of these hallmarks from multiple angles. For example, NAD+ enhancers and autophagy activators—both key components of RESTORIN—work in tandem. While NAD+ revitalizes mitochondria, mitophagy helps clear out damaged ones, creating a powerful one-two punch for energy production.
And there’s more: RESTORIN is designed to activate sirtuins, a group of longevity-associated enzymes that rely on NAD+ to maintain cellular health, including repairing DNA. Combine that with senolytics, which remove harmful (senescent) cells that promote aging, and the result is a product engineered to tackle aging from all sides. By blending technologies like mTOR inhibition, autophagy, and sirtuin activation, RESTORIN aims to counteract cellular aging in a way that could truly be groundbreaking.
Hope for the Future
Within the past few decades, there has been an upsurge in the prevalence of chronic diseases, including cardiovascular disease, dementia, diabetes, and cancer. These age-related diseases are some of the leading causes of death in the United States, where life expectancy has begun to decline. Furthermore, the population of individuals over 65 is expected to explode in the coming years, leading to more incidences of these diseases.
The goal and hope of aging biology research is to find how to delay aging processes and mitigate or prevent chronic diseases that shorten people’s lifespans. Thus far, researchers have found that lifestyle factors, such as poor diet and physical inactivity, contribute largely to these diseases. However, researchers are also finding how longevity-promoting lifestyle factors alter our biology. In many ways, it is for this reason that many of the longevity technologies of today have been discovered. By applying the latest discoveries in aging biology, the hope is to reduce the incidence of chronic diseases and maintain or even increase the life expectancy of individuals.
Written in partnership with Tom White
